Andrew Wolfe, Ph.D.
Director of Research Training
Division of Pediatric Endocrinology
The Johns Hopkins Hospital
Department of Pediatrics
600 N. Wolfe Street
Baltimore, MD 21287
Northwestern University (Evanston, Il) – Neuroscience
The Children's Hospital (Boston) - Research Fellow
Andrew Wolfe received his Ph.D. in neuroscience from Northwestern University. He completed his research fellowship at The Children’s Hospital in Boston, and was both Assistant Professor of Pediatrics and Basic Science Research Director in the division of pediatric endocrinology at The University of Chicago.
His research centers on understanding the development and functional regulation of the hypothalamic-pituitary-gonadal axis which controls reproduction. Because of a long-standing interest in the regulation of GnRH gene expression and in addition to performing standard in vitro analysis, his laboratory developed a variety of transgenic and knock out mouse models that have revealed both cis- and trans-regulatory elements underlying the cell-specific expression of GnRH.
His laboratory is also interested in understanding how metabolic status impacts reproductive function. It has long been known that states of negative energy balance are associated with infertility. These can include anorexia nervosa and can play an important component in functional hypothalamic amenorrhea. What has become clear in recent years is that states of positive energy balance, such as obesity and type II diabetes, are also associated with reproductive dysfunction. His laboratory has developed a mouse model of obesity induced infertility. Used in conjunction with mouse models of tissue-specific gene deletion, they are able to probe the role of various molecular signals mediating the effects of obesity on reproductive function.
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