Clinical trials actively recruiting participants:

Pediatric Inflammatory Bowel Disease; Pediatric Trial of Pharmacokinetics of Human Anti-TNF Monoclonal Antibody Adalimumab

• Principal Investigator: Maria Oliva-Hemker, MD
• Contact Vivian Abadom: 410-955-0779
• Description: Pediatric Trial of Pharmacokinetics of Human Anti-TNF Monoclonal Antibody Adalimumab Children: Enrolling children between the ages  of 6 and 17 years of age with Crohn's Disease for greater than 4 months for a multicenter trial.

Pediatric Inflammatory Bowel Disease: Pediatric IBD Registry Serology & Genetic Research

• Principal Investigator: Maria Oliva-Hemker, MD
• Contact Vivian Abadom: 410-955-0779
• Description:  Pediatric IBD Registry Serology & Genetic Research: Enrolling c hildren up to 16 years of age with NEWLY diagnosed of Inflammatory Bowel Disease (IBD) for a multicenter registry study.

Pediatric Inflammatory Bowel Disease: Pediatric DNA Microarray Study

• Principal Investigator: Maria Oliva-Hemker, MD
• Contact Vivian Abadom: 410-955-0779
• Description: Pediatric DNA Microarray Study: Enrolling children between the ages of 1 and 18 years of age having their first colonoscopy for evaluation of any gastrointestinal symptoms such as abdominal pain, blood in the stool or suspicion of IBD.

Pediatric Inflammatory Bowel Disease; Pediatric High-dose Cyclophosphamide for the Treatment of Severe Autoimmune Enteropathy

• Principal Investigator: Maria Oliva-Hemker, MD
• Contact Vivian Abadom: 410-955-0779
• Description: Pediatric High-dose Cyclophosphamide for the Treatment of Severe Autoimmune Enteropathy: Enrolling children between the ages of 6 and 17 years of age with Crohn's Disease

PROBE: PROspective study of Biliary atresia Epidemiology: A Prospective Database of Infants with Cholestasis
A protocol of the Biliary Atresia Research Consortium (BARC)

• Principal Investigator: Dr. Kathleen B. Schwarz
• Contact Robert A. Jurao: 410-955-1736
• Description: This research study is being conducted for two reasons:  The first is to collect medical information about children born with cholestatic liver disease and store it in a national database.  The second is to develop a repository (long-term storage) of samples of blood, urine, and tissue from children born with cholestatic liver disease.

BASIC: Biliary Atresia Study in Infants, Children and Adults
A protocol of the Biliary  Atresia Research Consortium (BARC)

• Principal Investigator: Dr. Kathleen B. Schwarz
• Contact Robert A. Jurao: 410-955-1736
• Description: This research study is being conducted to learn more about the natural history and causes of Biliary Atresia in children. This study is also being done to develop a repository (long-term storage) of samples of blood and urine from older children with Biliary Atresia to be used in research about liver disease.

START: A Randomized, Double-Blinded, Placebo-Controlled Trial of Corticosteroid Therapy Following Portoenterostomy in Infants with Biliary Atresia (IND 71,411): A Protocol of Biliary Atresia Research Consortium (BARC)

• Principal Investigator: Dr. Kathleen B. Schwarz
• Contact Aparna Roy: 410-955-9161
• Description: This clinical trial is being conducted to see if a steroid medicine can improve the outcome of infants who have surgery for biliary atresia.

Studies in Pediatric Liver Transplantation (S.P.L.I.T.) Multi-Center Data Registry

• Principal Investigator: Dr. Kathleen B. Schwarz
• Contact Mary Kay Alford: 410-955-9162; Robert A. Jurao: 410-955-1736
• Description: This research study is being conducted to enter scientific information on pediatric liver transplantation into a national database to learn more about how children do before and after liver transplant.

Functional Outcomes in Pediatric Liver Transplantation (Health Related Quality of Life)

• Principal Investigator: Dr. Kathleen B. Schwarz
• Contact Mary Kay Alford: 410-955-9162; Robert A. Jurao: 410-955-1736
• Description: This research study being conducted to compare the health-related quality of life (HRQOL) in children who have had liver transplants compared children who have not and to find out what factors effect HRQOL

Pediatric Acute Liver Failure Study Group Registry and Biological Samples

• Principal Investigator: Dr. Kathleen B. Schwarz
• Contact Mary Kay Alford: 410-955-9162; Robert A. Jurao: 410-955-1736
• Description: This research study is being conducted to obtain samples of blood and tissue, and clinical information from children with acute liver failure.  The information will be used to study acute liver failure in children. The laboratory tests will help us to identify viruses and other causes of acute liver failure.

Longitudinal Study of Genetic Causes of Intrahepatic Cholestasis
A protocol of the Cholestatic Liver Disease Consortium (CLiC)

• Principal Investigator: Dr. Kathleen B. Schwarz
• Contact Robert A. Jurao: 410-955-1736
• Description: This research study collects medical information, blood, urine, and tissue samples from children and young adults with the following liver diseases: Alagille syndrome, Alpha-1-Antitrypsin deficiency, Progressive familial intrahepatic cholestasis (PFIC), Bile acid synthesis defects. The information and samples will be part of a database. This information will help the researchers to learn more about these important diseases.