September 03, 2010
Ido Paz-Priel, M.D., left, with former oncology patient Clarissa Schilstra, holds a ceremonial check with John Hyland, Hyundai's regional representative, on Sept. 2 at Johns Hopkins.
Johns
Hopkins pediatric oncologist Ido Paz-Priel has received a $100,000 Hope Grant from
the Hyundai Hope on Wheels Foundation to fund research that may lead to a novel
therapeutic approach to managing multiple malignancies and inflammatory
conditions. Paz-Priel accepted the award Sept. 2, the beginning of National
Childhood Cancer Awareness Month, at the National Press Club in Washington,
D.C. The grant to fund “The C/EBP:NF-kB Complex: A
novel target in pediatric leukemia and lymphoma,”
is one of Hyundai’s 68 National Hope Grants announced that day.
WATCH Dr. Paz-Priel accept his check:
Acute
myeloid leukemia and lymphoma are leading causes of cancer-related deaths in
children. Apoptosis describes a cell’s programmed death. “Resistance to
apoptosis is a key feature of leukemia and lymphoma and a major obstacle on the
way to a cure,” says Paz-Priel, whose research tests the hypothesis that C/EBP,
a DNA binding protein that promotes the expression of certain genes, is
essential for the expression of anti-apoptotic genes in human lymphoma, through
interaction with the gene NF-kB p50.
“Dysregulated
apoptosis is an important feature of the malignant phenotype in hematologic
malignancies, contributing to the high rate of therapy failure,” says Donald
Small, director of pediatric oncology at the Sidney Kimmel Cancer Center at Johns Hopkins. “Ido is proposing an exciting series of experiments.”
Hyundai’s
Hope on Wheels Pediatric Cancer Research Grant, Small continues, “will enable Ido
to establish an independent research program that will provide a novel
therapeutic approach for children with leukemia and lymphoma.”
Since 1998, Hyundai Hope on Wheels has
donated more than $14 million to children’s hospitals nationwide to help kids
fight cancer. Every time a new Hyundai vehicle is sold in the United States $200 is donated to Hope on Wheels. In 2009,
Hyundai and its dealers presented Paz-Priel’s colleague, pediatric oncologist
Heather J. Symons, with a check for $35,000 to help fund her research into
allogeneic stem cell transplantation.
In a special recognition at Johns Hopkins
that afternoon, Sept. 2, Paz-Priel
accepted a ceremonial check from Hyundai representatives.