Hopkins Children’s Publications

Partners in Discovery

Winter 2008
The Jigsaw Puzzle of CF Lung Disease Severity
What is it in the genes and environment that really makes a difference? Why does one cystic fibrosis patient have only mild lung disease while another patient—with the same CFTR mutations—suffers severe lung disease? Are genes other than CFTR responsible for these variations? Or is the environment the cause?

Summer 2007
Studying the Science of Resistance
Pseudomonas aeruginosa is a nasty bug, infecting nearly 80 percent of all CF patients. And its success lies in part to its reputation for resisting many common antibiotics thrown at it. In fact, although immediate treatment with antibiotics can clear the infection, in many cases the bacteria adapt and establish permanent colonies in the lungs, increasing sputum production and decreasing lung function.

Fall 2006
Advancing the Knowledge
A distinct advantage to being a patient of The Johns Hopkins Cystic Fibrosis Center is that the doctors you see regularly are contributing significantly to the understanding and management of cystic fibrosis worldwide.