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Kwang Sik Kim, M.D.

Kwang Sik Kim, M.D.

Director, Eudowood Division of Pediatric Infectious Diseases


Infectious Diseases


Division of Pediatric Infectious Diseases
David M. Rubenstein Child Health Building
200 N. Wolfe Street, Room 3148
Baltimore, MD  21287


Medical School: Seoul National University, Korea


  • Ellis Hospital in New York
  • Louisiana State University Division, Charity Hospital of Louisiana


Kwang Sik Kim, M.D., directs the Eudowood Division of Pediatric Infectious Diseases at Hopkins Children’s. As a researcher, his chief interest is in the pathogenesis of sepsis and central nervous system (CNS) infections, using microbial genomics and proteomics. Sepsis and CNS infections are prevalent and remain the major causes of mortality and morbidity throughout the world; attempts to control such diseases have been hampered by incomplete knowledge of the pathogenesis. Kim’s group is the first to show, using E. coli, how bacteria translocate from blood to the CNS. His group is also one of the first to show that endotoxin requires soluble CD14 for activating endothelial cells. His continued investigations of microbes-host interactions pertaining to pathogenesis will lead to development of novel strategies (e.g., vaccines) to prevent sepsis and CNS infections.

Kim received his medical degree in 1971 from the Seoul National University in Korea. After serving three years in the Korean Air Force, he trained in pediatrics at Ellis Hospital in New York and Louisiana State University Division, Charity Hospital of Louisiana. A former fellow in pediatric infectious diseases at Harbor-UCLA Medical Center, UCLA School of Medicine, he left his post there as director of infectious diseases to join Johns Hopkins in 2000 as director of pediatric infectious diseases. At Hopkins, he holds a joint appointment in molecular microbiology and immunology at the Johns Hopkins Bloomberg School of Public Health.


Dr. Kim’s scientific contribution has been in the area of central nervous system (CNS) infection. The CNS infection continues to be an important cause of mortality and morbidity, and a major contributing factor to such mortality and morbidity is our incomplete understanding of the pathogenesis of this disease. Dr. Kim’s research program has been at the cutting edge of advancing our knowledge on the pathogenesis, prevention and therapy of CNS infection by elucidating the mechanisms involved in microbial penetration of the blood-brain barrier, which has been supported by the NIH RO1 grants since 1984, resulting in a total of 312 peer-reviewed original publications and 44 symposia and book chapters. The current knowledge on how meningitis-causing pathogens traverse the blood-brain barrier is largely derived from Dr. Kim’s program.

Dr. Kim’s laboratory was the first to demonstrate how CNS-infecting pathogens penetrate the blood-brain barrier. Dr. Kim’s laboratory using E. coli is the first to develop the novel concept that microbial penetration of the blood-brain barrier exploits specific microbial factors and host factors, involving microbe- and host-signal transduction pathways. Dr. Kim’s laboratory using E. coli is the first to exploit the microbial genome sequencing information for elucidating the pathogenesis of CNS infection. The novel concept derived from E. coli is shown to be relevant to penetration of the blood-brain barrier by other CNS-infecting pathogens, such as group B Streptococcus, Listeria monocytogenes, Streptococcus pneumoniae, Neisseria meningitides, Citrobacter spp, Mycobacterium tuberculosis, Anthrax bacillus, Borrelia spp, Candida albicans, Acanthamoeba, Cryptococcus neoformans, Trypanosome spp, Toxoplasma, Plasmodium falciparum, HIV-1, measles virus, enteroviruses and West Nile virus.

Phone: 410-614-3917

Fax: 410-614-1491

Email: kwangkim@jhmi.edu

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